![]() Affected foals do not survive past the first six months of life. Inherited as an autosomal recessive disorder, SCID has been identified in horses of Arabian and part-Arabian descent. Phenotype: Severe combined immunodeficiency (SCID) foals are normal at birth but soon present signs such as elevated temperature, respiratory stress, and diarrhea at an early age, typically between 2-8 weeks of age. Severe combined immunodeficiency (SCID) is a disease that causes foals to be born with severely weakened immune systems. The Journal of Immunology 1997 158:3565-3569. Click here for Price and Turnaround Time. A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation. SCID/SCID: Horse has two copies of the mutation associated with SCID. N/SCID: Horse has one copy of the mutation associated with SCID. N/n: Horse does not carry the mutation associated with SCID. However, there is a 50% chance it will pass the variant to its offspring, so mating to other carriers should be avoided to prevent the birth of an affected foal. ![]() If a horse is a carrier (n/SCID), it will not show any clinical signs of SCID. SCID is a recessive disorder so two copies of the defective version of the DNA-PK gene must be inherited (SCID/SCID) for a foal to be affected. ![]() SCID cannot be cured and affected foals will usually die from an infection before 6 months of age. Once the maternal immune protection wears off, SCID foals develop signs of infection (examples including fever, respiratory distress and/or diarrhea). ![]() Foals affected by SCID lack a proper immune system which is critical for fighting infection. ![]()
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